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Effect of pyrroloquinoline quinone on neuropathic pain following chronic constriction injury of the sciatic nerve in rats

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Moreover, an enormous amount of time, labor, and cost are needed to optimize and improvements needed to translate each stimulus-based NM from the preclinical to clinical stage apart from endogenous triggers such as pH and temperature, as this varies depending from one person to another

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in 44.8%, the onset-to-door time was 4.5 hours (median 5.5 hours [IQR 2.213.4]), and 25.2% of patients received any reperfusion therapy, IV thrombolysis in 23% (Figure 2)